工艺成果例: 1.抗尿频尿急药物“曲司氯铵”工业化生产; 2.骨质疏松治疗药物“醋酸巴多昔芬”中试生产(公斤级); 3.抗老年痴呆症药物“石杉碱甲”的工业化生产; 4.胆道药物“烟苄酯”工业化生产。 论文成果例: 1. Identification of potential AMPK activator by pharmacophore modeling,molecular docking and QSAR study. Computational Biology and Chemistry. 2. Discovery of novel wee1 inhibitors via structure-based virtual screening and biological evaluation. Journal of Computer-Aided Molecular Design. 3. Pharmacophore modeling, molecular docking and molecular dynamics simulations toward identifying lead compounds for Chk1.Computational Biology and Chemistry. 4. Pharmacophore modeling, molecular docking and molecular dynamics studies on natural products database to discover novel skeleton as non-purine xanthine oxidase inhibitors.Journal of Receptors and Signal Transduction 5. Computational Analysis of Artimisinin Derivatives on the Antitumor Activities.Nat. Prod. Bioprospect. 6. Discovery of novel dual binding TNKS inhibitors of Wnt Signaling Inhibition by pharmacophore modeling, molecular docking and bioassay. Molecular BioSystems. 7. TNKS inhibitors of Wnt Signaling Inhibition by pharmacophore modeling, molecular docking and bioassay. Molecular BioSystems. 专利成果例: 1.一种2-羟基-2,2-二苯基乙酸-3α-(8-氮杂双环[3,2,1])-3-辛酯的制备方法 ZL201210518490.5。 2.一种卡波姆及其制备方法。ZL201510149001.7。 |